Jin Nakahara, M.D., Ph.D.
Project Assistant Professor, Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan.
Research Interest: Multiple Sclerosis (Development of remyelination medicines for therapeutic uses).
[Japanese version is here]

<Education>
1992: Rocky River Middle School, Ohio, USA.
1997: Seishin-Gakuen High School, Ibaraki, Japan.
2003: Keio University School of Medicine, Tokyo, Japan. (M.D.)
2007: Keio University Graduate School of Medicine, Tokyo, Japan. (Ph.D.)


<Previous and present positions>
2003-2005: Resident, Department of Internal Medicine, Keio University Hospital, Tokyo, Japan.
2003-2004: COE Researcher (RA), The 21st COE Program at Keio University, Tokyo, Japan.
2004-2007: JSPS Research Fellow (DC1), Japan Society for the Promotion of Science, Japan.
2007-2008: JSPS Research Fellow (PD), Japan Society for the Promotion of Science, Japan.
2008-2011: Assistant Professor, Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan.
2011-present: Project Assistant Professor, Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan.


<Research activities>
1999-present: Department of Anatomy, Keio University School of Medicine, Tokyo, Japan (Prof. Koki Kawamura, Prof. Sadakazu Aiso).
2000-2008: Department of Neurobiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan (Dr. Hiroaki Asou).
2007-present: Department of Neurology, Keio University School of Medicine, Tokyo, Japan (Prof. Norihiro Suzuki).
2008-present: Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan.


<Awards>
2001: Honary Award, from the dean of Keio University Schol of Medicine.
2003: Presidential Award, from the president of Keio University.
2005: Elected Participant, to 55th Meeting of Nobel Laureates in Lindau, from Ministry of Education, Culture, Sports, Science and Technology of Japan.
2007: Travel Award, from the 23rd Congress of the European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS 2007).
2007: Best Poster Presentation Award, from the 23rd Congress of the European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS 2007).
2008: Travel Award, from World Congress on Treatment and Research in Multiple Sclerosis (WCTRIMS).
2010: Best Poster Presentation Award, from the 3rd Congress of the Pan-Asian Committee for the Treatment and Research in Multiple Sclerosis (PACTRIMS 2010).
2011: Best Oral Presentation Award, from the 52nd Annual Meeting of Japanese Society of Neurology.


<Publications (articles in English; as first and/or corresponding author)>
1) Nakahara J, Tan-Takeuchi K, Seiwa C, Yagi T, Aiso S, Kawamura K, and Asou H.
Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia.
Neuroscience Letters, 298:163-166, 2001. [PubMed]
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2) Kaifu T, Nakahara J (co-first author), Inui M, Mishima K, Momiyama T, Kaji M, Sugahara A, Koito H, Ujike-Asai A, Nakamura A, Kanazawa K, Tan-Takeuchi K, Iwasaki K, Yokoyama WM, Kudo A, Fujiwara M, Asou H and Takai T.
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.
The Journal of Clinical Investigation, 111:323-332, 2003. [PubMed]
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3) Nakahara J (corresponding author), Seiwa C, Shibuya A, Aiso S and Asou H.
Expression of Fc receptor for IgM in oligodendrocytes and myelin of mouse central nervous system.
Neuroscience Letters, 337:73-76, 2003. [PubMed]
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4) Nakahara J, Takeumura M, Gomi H, Tsunematsu K, Itohara S, Asou H, Ogawa M, Aiso S and Tan-Takeuchi K.
The role of radial fibers in controlling the onset of myelination.
Journal of Neuroscience Research, 72:279-289, 2003. [PubMed]
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5) Nakahara J (corresponding author), Tan-Takeuchi K, Seiwa C, Gotoh M, Kaifu T, Ujike A, Inui M, Yagi T, Ogawa M, Aiso S, Takai T and Asou H.
Signaling via immunoglobulin Fc receptors induce oligodendroglial differentiation and myelination.
Developmental Cell, 4:841-852, 2003. [PubMed]
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6) Nakahara J (corresponding author), Seiwa C, Tan-Takeuchi K, Gotoh M, Kisihiara K, Ogawa M, Asou H and Aiso S.
Involvement of CD45 in central nervous system myelination.
Neuroscience Letters, 379:116-121, 2005. [PubMed]
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7) Nakahara J (corresponding author) and Aiso S.
Fc receptor-positive cells in remyelinating multiple sclerosis lesions.
Journal of Neuropathology and Experimental Neurology, 65:582-591, 2006. [PubMed]
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8) Nakahara J (corresponding author), Kanekura K, Nawa M, Aiso S and Suzuki N.
Abnormal expression of TIP30 and arrested nucleocytplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.
The Journal of Clinical Investigation, 119:169-181, 2009. [PubMed]
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9) Nakahara J (corresponding author), Aiso S and Suzuki N.
Factors that retard remyelination in multiple sclerosis with a focus on TIP30: a novel therapeutic target.
Expert Opinion on Therapeutic Targets, 13:1375-1386, 2010. [PubMed]
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10) Nakahara J (corresponding author), Aiso S and Suzuki N.
Autoimmune versus oligodendrogliopathy: the pathogenesis of multiple sclerosis.
Archivum Immunologiae et Therapiae Experimentalis, 58:325-333, 2010. [PubMed]


<Publications (articles in English; as co-author)>
1) Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I and Kouyama K.
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
European Journal of Neuroscience, 19:2826-2838, 2004. [PubMed]
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2) Seiwa C, Nakahara J, Komiyama T, Katsu Y, Iguchi T and Asou H.
Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells.
Neuroendocrinology, 80:21-30, 2004. [PubMed]
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3) Awaya N, Adachi A, Mori T, Kamata H, Nakahara J, Yokoyama K, Yamada T, Kizaki M, Sakamoto M, Ikeda Y and Okamoto S.
Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma.
Leukeima Research, 30:1059-1062, 2005. [PubMed]
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4) Yamamoto M, Yoshimura K, Kitada M, Nakahara J, Seiwa C, Ueki T, Shimoda Y, Ishige A, Watanabe K, Asou H.
A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1).
Journal of Neuroscience Research, 87:503-513 2009. [PubMed]


<Publications (articles in Japanese)>
1) Nakahara J and Aiso S.
The mechanism of cenral nervous system myelination (author's translation).
Saibou, 34-37, May, 2003.
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2) Nakahara J and Asou H.
The mechanism of central nervous system myelination (author's translation).
Seikagaku, 395-399, May, 2003.
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3) Nakahara J.
Elucidating the mechanism of central nervous system myelination for the cure of multiple sclerosis (author's translation).
Igaku-no-Ayumi, 985-986, September, 2003.
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4) Tan-Takeuchi K, Nakahara J and Aiso S.
Involvement of astrocytes in controlling the onset of myelination (author's translation).
Seitai-no-Kagaku, 162-166, May-June, 2006.
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5) Nakahara J and Aiso S.
Demyelination and remyelination in multiple sclerosis lesions (author's translation).
Seitai-no-Kagaku, 203-212, May-June, 2006.
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6) Nakahara J.
Structure, function and biochemistry of myelin (author's translation).
Clinical Neuroscience, 1214-1217, Nov, 2009.
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7) Nakahara J.
Pathophysiology of multiple sclerosis (author's translation).
Naika, 762-767, May, 2010.


<Publications (books)>
1) Nakahara J.
"Multiple Sclerosis" and "Acute Disseminating Encephalomyelitis" section.
Shinkei-Naika Golden Handbook, edited by Suzuki N, Nan-Ko-Do (in press) (in Japanese).


<Presentations at international conferences (as first author)>
1) Nakahara J, Tan-Takeuchi K, Seiwa C, Yagi T, Aiso S, Kawamura K and Asou H.
MBP is required for the regulation of MAG in oligodendroglia (Poster).
XV International Symposium on Morphological Sciences, September 18-21, 2000 (Kyoto, Japan).
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2) Nakahara J, Aiso S, Takai T and Asou H.
The gamma chain of immunoglobulin Fc receptors triggers myelinogenesis of oligodendroglia (Oral).
32nd Annual Meeting, Society for Neuroscience, November 2-9, 2002 (Orlando, USA).
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3) Nakahara J.
Role of immunological molecules in CNS myelination (Invited speaker).
16th International Congress of the IFAA, August 22-27, 2004 (Kyoto, Japan).
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4) Nakahara J and Aiso S.
Fc receptor-positive oligodendrocyte precursor cells in remyelinating multiple sclerosis lesions (Poster).
36th Annual Meeting, Society for Neuroscience, October 14-18, 2006 (Atlanta, USA).
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5) Nakahara J, Aiso S and Suzuki N.
Altered nucleocytoplasmic transport as a cause of remyelination failure in multiple sclerosis: a novel paradigm (Poster and oral as a prize awardee).
23rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), October 11-14, 2007 (Prague, Czech).
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6) Nakahara J, Kanekura K, Nawa M, Aiso S and Suzuki N.
Identification of a factor inhibiting nucleocytoplasmic transport and differentiation within preserved oligodendrocyte precursor cells in multiple sclerosis: a possible cause for remyelination failure.
World Congress on Treatment and Research in Multiple Sclerosis, September 17-20, 2008 (Montreal, Canada).
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7) Nakahara J, Hikishima K, Inoue T, Takeuchi H, Toyota F, Kanekura K, Nawa M, Ishii H, Tsutsumi H, Yamada M, Momoshima S, Okano H, Itoh T, Suzuki N and Aiso S.
Fc receptor-positive oligodendrocyte precursor cells in primate experimental autoimmune encephalomyelitis.
25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), September 9-12, 2009 (Dusseldorf, Germany).
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8) Nakahara J, Seiwa C, Aiso S and Suzuki N.
Preliminary design of remyelination medicine for chronic multiple sclerosis patients.
2nd Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS), November 20-21, 2009 (Hong Kong, China).
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9) Nakahara J, Maeda M, Aiso S and Suzuki N.
FcRgamma-targeting antibody induces the maturation of oligodendrocytes.
3rd Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS), August 26-28, 2010 (Bali, Indonesia).


<Patent>
1) No. 4214249 (Japan; registerd: Nov. 14th, 2008) (http://jstore.jst.go.jp/EN/detail.cgi?foreign_id=1231&_from=contents_list)
Nakahara J, Asou H and Aiso S. (from Keio University IPO)
Medical compositions containing Fc receptor gamma-chain activator.
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1) No. 7901678 (U.S.; registerd: Mar. 8th, 2011)
Nakahara J, Asou H and Aiso S. (from Keio University IPO)
Medicinal compositions containing Fc receptor gamma-chain activator.


<Patent pending>
1) PCT/JP2008/063838
Nakahara J, Aiso S and Suzuki N. (from Keio University IPO)
Novel drug delivery system and disease monitoring system for demyelinating diseases.
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<Languages spoken>
Japanese; native.
English; fluent.


<Contact address>
Rm#3S1, Center for Integrated Medical Research, Keio University School of Medicine.
35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Tel: +81-3-3353-1211 (x63573), Fax: +81-3-5360-1524, E-mail: nakahara@jnn.sakura.ne.jp